Title : Dedifferentiation of cultured thyroid cells by epidermal growth factor: some insights into the mechanism.

Pub. Date : 1987 Feb

PMID : 3030848






2 Functional Relationships(s)
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1 It has been possible to discriminate between the proliferative and dedifferentiating actions of EGF using amiloride, a non-specific inhibitor of the Na+/H+ antiporter. Amiloride epidermal growth factor Homo sapiens
2 An optimum concentration of amiloride (0.1 mM) was able to block EGF-stimulated incorporation of [3H]thymidine into DNA without preventing the blockade of iodide uptake, which implies that dedifferentiation is not a consequence of proliferation. Amiloride epidermal growth factor Homo sapiens