Title : Co-administration of nuciferine reduces the concentration of metformin in liver via differential inhibition of hepatic drug transporter OCT1 and MATE1.

Pub. Date : 2018 Nov

PMID : 30294927






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The data demonstrated that nuciferine significantly reduced metformin accumulation in MDCK cells stably expressing human OCT1 (MDCK-hOCT1) or hMATE1 (MDCK-hMATE1), and primary cultured mouse hepatocytes. Metformin solute carrier family 22 member 1 Homo sapiens
2 Furthermore, the presence of nuciferine in the basal compartment caused a concentration-dependent reduction of intracellular metformin accumulation in MDCK-hOCT1/hMATE1 cell monolayers. Metformin solute carrier family 22 member 1 Homo sapiens