Pub. Date : 2018 Oct 6
PMID : 30291731
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Autophagy inhibition-enhanced assembly of the NLRP3 inflammasome is associated with cisplatin-induced acute injury to the liver and kidneys in rats. | Cisplatin | NLR family, pyrin domain containing 3 | Rattus norvegicus |
| 2 | Western blot and immunohistochemical analyses showed that expression of NLRP3, caspase-1 and interleukin-1beta was upregulated significantly in a dose-dependent manner after cisplatin exposure. | Cisplatin | NLR family, pyrin domain containing 3 | Rattus norvegicus |
| 3 | These data suggested that cisplatin might activate NLRP3 by inhibiting autophagy in the liver and kidneys of rats. | Cisplatin | NLR family, pyrin domain containing 3 | Rattus norvegicus |