Pub. Date : 2018 Nov
PMID : 30290222
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Idebenone is a cytoprotective insulin sensitizer whose mechanism is Shc inhibition. | idebenone | SHC adaptor protein 1 | Homo sapiens |
| 2 | Of the 7 drugs, idebenone dose-dependently bound Shc protein in the 50-100 nM range, and induced insulin sensitivity and cytoprotection in this same 100 nM range that clinically dosed idebenone reaches in human plasma. | idebenone | SHC adaptor protein 1 | Homo sapiens |
| 3 | Multiple assays of target engagement demonstrate that idebenone physically interacts with Shc protein. | idebenone | SHC adaptor protein 1 | Homo sapiens |
| 4 | Thus, idebenone is the first-in-class member of a novel category of insulin-sensitizing and cytoprotective agents, the Shc inhibitors. | idebenone | SHC adaptor protein 1 | Homo sapiens |