Title : Interactions of the tricyclic antidepressant drug amitriptyline with L-DOPA in the striatum and substantia nigra of unilaterally 6-OHDA-lesioned rats. Relevance to motor dysfunction in Parkinson's disease.

Pub. Date : 2018 Dec

PMID : 30290201






1 Functional Relationships(s)
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1 Amitriptyline administered alone or jointly with L-DOPA had no effect on DAT binding on the lesioned side, significantly decreased SERT binding in the striatum and SN while NET binding only in the SN. Amitriptyline solute carrier family 6 member 4 Rattus norvegicus