Title : HIV-1 Nef Hijacks Lck and Rac1 Endosomal Traffic To Dually Modulate Signaling-Mediated and Actin Cytoskeleton-Mediated T Cell Functions.

Pub. Date : 2018 Nov 1

PMID : 30282749






2 Functional Relationships(s)
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1 Strikingly, the Nef-induced Lck compartment contains signaling-competent forms (phosphorylated on key Tyr residues) of Lck and some of its downstream effectors, TCRzeta, ZAP70, SLP76, and Vav1, avoiding the proximal LAT adaptor. Tyrosine LCK proto-oncogene, Src family tyrosine kinase Homo sapiens
2 Strikingly, the Nef-induced Lck compartment contains signaling-competent forms (phosphorylated on key Tyr residues) of Lck and some of its downstream effectors, TCRzeta, ZAP70, SLP76, and Vav1, avoiding the proximal LAT adaptor. Tyrosine LCK proto-oncogene, Src family tyrosine kinase Homo sapiens