Title : CLA-supplemented diet accelerates experimental colorectal cancer by inducing TGF-β-producing macrophages and T cells.

Pub. Date : 2019 Jan

PMID : 30279515






6 Functional Relationships(s)
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Protein Name
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1 Conjugated linoleic acid (CLA) has been shown to activate the nuclear receptor PPAR-gamma and modulate metabolic and immune functions. Linoleic Acids, Conjugated peroxisome proliferator activated receptor gamma Mus musculus
2 Conditional deletion of PPAR-gamma in macrophages from mice supplemented with CLA diet resulted in loss of this protective effect of CLA, suggesting a PPAR-gamma-dependent mechanism mediated by macrophages. Linoleic Acids, Conjugated peroxisome proliferator activated receptor gamma Mus musculus
3 Conditional deletion of PPAR-gamma in macrophages from mice supplemented with CLA diet resulted in loss of this protective effect of CLA, suggesting a PPAR-gamma-dependent mechanism mediated by macrophages. Linoleic Acids, Conjugated peroxisome proliferator activated receptor gamma Mus musculus
4 Conditional deletion of PPAR-gamma in macrophages from mice supplemented with CLA diet resulted in loss of this protective effect of CLA, suggesting a PPAR-gamma-dependent mechanism mediated by macrophages. Linoleic Acids, Conjugated peroxisome proliferator activated receptor gamma Mus musculus
5 Conditional deletion of PPAR-gamma in macrophages from mice supplemented with CLA diet resulted in loss of this protective effect of CLA, suggesting a PPAR-gamma-dependent mechanism mediated by macrophages. Linoleic Acids, Conjugated peroxisome proliferator activated receptor gamma Mus musculus
6 However, CLA supplementation significantly worsened colorectal tumor formation induced by azoxymethane and DSS by inducing macrophage and T-cell-producing TGF-beta via PPAR-gamma activation. Linoleic Acids, Conjugated peroxisome proliferator activated receptor gamma Mus musculus