Pub. Date : 2019 Jan
PMID : 30279515
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Conjugated linoleic acid (CLA) has been shown to activate the nuclear receptor PPAR-gamma and modulate metabolic and immune functions. | Linoleic Acids, Conjugated | peroxisome proliferator activated receptor gamma | Mus musculus |
2 | Conditional deletion of PPAR-gamma in macrophages from mice supplemented with CLA diet resulted in loss of this protective effect of CLA, suggesting a PPAR-gamma-dependent mechanism mediated by macrophages. | Linoleic Acids, Conjugated | peroxisome proliferator activated receptor gamma | Mus musculus |
3 | Conditional deletion of PPAR-gamma in macrophages from mice supplemented with CLA diet resulted in loss of this protective effect of CLA, suggesting a PPAR-gamma-dependent mechanism mediated by macrophages. | Linoleic Acids, Conjugated | peroxisome proliferator activated receptor gamma | Mus musculus |
4 | Conditional deletion of PPAR-gamma in macrophages from mice supplemented with CLA diet resulted in loss of this protective effect of CLA, suggesting a PPAR-gamma-dependent mechanism mediated by macrophages. | Linoleic Acids, Conjugated | peroxisome proliferator activated receptor gamma | Mus musculus |
5 | Conditional deletion of PPAR-gamma in macrophages from mice supplemented with CLA diet resulted in loss of this protective effect of CLA, suggesting a PPAR-gamma-dependent mechanism mediated by macrophages. | Linoleic Acids, Conjugated | peroxisome proliferator activated receptor gamma | Mus musculus |
6 | However, CLA supplementation significantly worsened colorectal tumor formation induced by azoxymethane and DSS by inducing macrophage and T-cell-producing TGF-beta via PPAR-gamma activation. | Linoleic Acids, Conjugated | peroxisome proliferator activated receptor gamma | Mus musculus |