Pub. Date : 2018 Dec
PMID : 30272260
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | LY3009120, a pan-Raf kinase inhibitor, inhibits adipogenesis of 3T3-L1 cells by controlling the expression and phosphorylation of C/EBP-alpha, PPAR-gamma, STAT-3, FAS, ACC, perilipin A, and AMPK. | LY3009120 | signal transducer and activator of transcription 3 | Mus musculus |
| 2 | LY3009120 reduced not only the expression of CCAAT/enhancer-binding protein-alpha (C/EBP-alpha), peroxisome proliferator-activated receptor-gamma (PPAR-gamma), fatty acid synthase (FAS), acetyl CoA carboxylase (ACC), and perilipin A, but also reduced the phosphorylation of signal transducer and activator of transcription-3 (STAT-3) in differentiating 3T3-L1 cells. | LY3009120 | signal transducer and activator of transcription 3 | Mus musculus |
| 3 | LY3009120 reduced not only the expression of CCAAT/enhancer-binding protein-alpha (C/EBP-alpha), peroxisome proliferator-activated receptor-gamma (PPAR-gamma), fatty acid synthase (FAS), acetyl CoA carboxylase (ACC), and perilipin A, but also reduced the phosphorylation of signal transducer and activator of transcription-3 (STAT-3) in differentiating 3T3-L1 cells. | LY3009120 | signal transducer and activator of transcription 3 | Mus musculus |
| 4 | In summary, this is the first report, to the best of our knowledge, demonstrating that LY3009120 has an anti-adipogenic effect on 3T3-L1 cells, which may be mediated through control of the expression and phosphorylation of C/EBP-alpha, PPAR-gamma, STAT-3, FAS, ACC, perilipin A, and AMPK. | LY3009120 | signal transducer and activator of transcription 3 | Mus musculus |