Title : Increase of PRPP enhances chemosensitivity of PRPS1 mutant acute lymphoblastic leukemia cells to 5-Fluorouracil.

Pub. Date : 2018 Dec

PMID : 30255549






1 Functional Relationships(s)
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1 Mechanistically, PRPS1 mutants increase the level of intracellular phosphoribosyl pyrophosphate (PRPP), which causes the apt conversion of 5-FU to FUMP and FUTP in Reh cells, to promote 5-FU-induced DNA damage and apoptosis. FUMP phosphoribosyl pyrophosphate synthetase 1 Homo sapiens