Title : A Dual Noradrenergic Mechanism for the Relief of Neuropathic Allodynia by the Antidepressant Drugs Duloxetine and Amitriptyline.

Pub. Date : 2018 Nov 14

PMID : 30249798






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1 We then conducted a transcriptomic analysis in dorsal root ganglia, which suggested that the peripheral component of duloxetine action involves the inhibition of neuroimmune mechanisms accompanying nerve injury, including the downregulation of the TNF-alpha-NF-kappaB signaling pathway. Duloxetine Hydrochloride tumor necrosis factor Homo sapiens