Pub. Date : 2019 Jan 16
PMID : 30247877
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Alpha-7 Nicotinic Receptor-Targeted Cinobufagin Induces Antinociception and Inhibits NF-kappaB Signaling Pathway in DRG Neurons. | cinobufagin | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 2 | As shown in the hot-plate test, formalin test, and acetic acid writhing test in mice, administration of CBG produced significant antinociceptive activity in a dose-dependent manner, and the antinociceptive effect was blocked by intraperitoneal pretreatment of methyllycaconitine citrate (an alpha7 nicotinic receptor antagonist) and intrathecal delivery of an alpha7 nicotinic receptor antagonist siRNA (alpha7-siRNA). | cinobufagin | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 3 | As shown in the hot-plate test, formalin test, and acetic acid writhing test in mice, administration of CBG produced significant antinociceptive activity in a dose-dependent manner, and the antinociceptive effect was blocked by intraperitoneal pretreatment of methyllycaconitine citrate (an alpha7 nicotinic receptor antagonist) and intrathecal delivery of an alpha7 nicotinic receptor antagonist siRNA (alpha7-siRNA). | cinobufagin | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 4 | In the chemical pain models and primary cultured DRG neurons, Western blot analysis showed that the formation of p-IkappaB and p-NF-kappaB was regulated by CBG, and the effect of CBG was inhibited by alpha7-siRNA, and ELISA analysis indicated that CBG also regulated the expression of inflammatory cytokines through the alpha7 nicotinic receptor in DRG. | cinobufagin | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 5 | In the chemical pain models and primary cultured DRG neurons, Western blot analysis showed that the formation of p-IkappaB and p-NF-kappaB was regulated by CBG, and the effect of CBG was inhibited by alpha7-siRNA, and ELISA analysis indicated that CBG also regulated the expression of inflammatory cytokines through the alpha7 nicotinic receptor in DRG. | cinobufagin | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 6 | These results suggest that CBG may activate an alpha7 nicotinic receptor, thereby triggering the inhibition of the DRG NF-kappaB signaling pathway, resulting in an antinociceptive effect in mice. | cinobufagin | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |