Title : Alpha-7 Nicotinic Receptor-Targeted Cinobufagin Induces Antinociception and Inhibits NF-κB Signaling Pathway in DRG Neurons.

Pub. Date : 2019 Jan 16

PMID : 30247877






6 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Alpha-7 Nicotinic Receptor-Targeted Cinobufagin Induces Antinociception and Inhibits NF-kappaB Signaling Pathway in DRG Neurons. cinobufagin cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 As shown in the hot-plate test, formalin test, and acetic acid writhing test in mice, administration of CBG produced significant antinociceptive activity in a dose-dependent manner, and the antinociceptive effect was blocked by intraperitoneal pretreatment of methyllycaconitine citrate (an alpha7 nicotinic receptor antagonist) and intrathecal delivery of an alpha7 nicotinic receptor antagonist siRNA (alpha7-siRNA). cinobufagin cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
3 As shown in the hot-plate test, formalin test, and acetic acid writhing test in mice, administration of CBG produced significant antinociceptive activity in a dose-dependent manner, and the antinociceptive effect was blocked by intraperitoneal pretreatment of methyllycaconitine citrate (an alpha7 nicotinic receptor antagonist) and intrathecal delivery of an alpha7 nicotinic receptor antagonist siRNA (alpha7-siRNA). cinobufagin cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
4 In the chemical pain models and primary cultured DRG neurons, Western blot analysis showed that the formation of p-IkappaB and p-NF-kappaB was regulated by CBG, and the effect of CBG was inhibited by alpha7-siRNA, and ELISA analysis indicated that CBG also regulated the expression of inflammatory cytokines through the alpha7 nicotinic receptor in DRG. cinobufagin cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
5 In the chemical pain models and primary cultured DRG neurons, Western blot analysis showed that the formation of p-IkappaB and p-NF-kappaB was regulated by CBG, and the effect of CBG was inhibited by alpha7-siRNA, and ELISA analysis indicated that CBG also regulated the expression of inflammatory cytokines through the alpha7 nicotinic receptor in DRG. cinobufagin cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
6 These results suggest that CBG may activate an alpha7 nicotinic receptor, thereby triggering the inhibition of the DRG NF-kappaB signaling pathway, resulting in an antinociceptive effect in mice. cinobufagin cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus