Title : A feedback loop between dipeptide-repeat protein, TDP-43 and karyopherin-α mediates C9orf72-related neurodegeneration.

Pub. Date : 2018 Oct 1

PMID : 30239641






1 Functional Relationships(s)
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1 Accumulating cytosolic, but not insoluble aggregated TDP-43 caused karyopherin-alpha2/4 (KPNA2/4) pathology, increased levels of dipeptide-repeat proteins and enhanced G4C2-related toxicity. Dipeptides TAR DNA-binding protein-43 homolog Drosophila melanogaster