CPRiL

Protein Name	TAR DNA-binding protein-43 homolog
Organism	Drosophila melanogaster
Gene ID	37781
Gene Symbol	TBPH
UniProt	Q8SXP8 (Q8SXP8_DROME), Q9W1I0 (Q9W1I0_DROME)
Relationships	Total Number of functionally related compound(s) : 249 Total Number of Articles : 196
Description	TAR DNA-binding protein-43 homolog
Gene Summary	Enables GU repeat RNA binding activity and single-stranded DNA binding activity. Involved in several processes, including adult walking behavior; negative regulation of synaptic assembly at neuromuscular junction; and synapse organization. Located in H zone; nucleus; and perinuclear region of cytoplasm. Is expressed in several structures, including central nervous system; embryonic/larval midgut primordium; ganglia; glial cell; and somatic muscle cell. Used to study amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 10; frontotemporal dementia; and neurodegenerative disease. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 10; and motor neuron disease. Orthologous to human TARDBP (TAR DNA binding protein). [provided by Alliance of Genome Resources, Jul 2025]
synonyms	TAR DNA-binding protein-43 homolog CG10327-PA CG10327-PB CG10327-PC CG10327-PD CG10327-PE CG10327-PF TAR DNA binding protein TBPH-PA TBPH-PB TBPH-PC TBPH-PD TBPH-PE TBPH-PF Tar DNA binding protein homolog Dmel_CG10327 CG10327 Dmel\CG10327 TDP-43 TDP43 TDPH Tbph dTBPH dTDP dTDP-43 dmTDP43 dtar tbph Click to show/hide the synonyms
Properties