Pub. Date : 2018 Oct
PMID : 30237126
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Mus musculus |
| 2 | In addition, our study also identified that the activation of c-Jun N-terminal kinase1/2 (JNK1/2) was regulated by RIPK3, which mediated curcumol-induced ROS production. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Mus musculus |
| 3 | In addition, our study also identified that the activation of c-Jun N-terminal kinase1/2 (JNK1/2) was regulated by RIPK3, which mediated curcumol-induced ROS production. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Mus musculus |
| 4 | The use of specific JNK1/2 inhibitor (SP600125) resulted in the suppression of curcumol-induced ROS production and mitochondrial depolarization, which in turn, contributed to the inhibition of curcumol-triggered necroptosis. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Mus musculus |
| 5 | In summary, our study results reveal the molecular mechanism of curcumol-induced HSC necroptosis, and suggest a potential clinical use of curcumol-targeted RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling for the treatment of hepatic fibrosis. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Mus musculus |