Title : The conserved threonine-rich region of the HCF-1PRO repeat activates promiscuous OGT:UDP-GlcNAc glycosylation and proteolysis activities.

Pub. Date : 2018 Nov 16

PMID : 30224358






2 Functional Relationships(s)
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1 OGT thereby stably glycosylates serines and threonines of numerous proteins and, via a transient glutamate glycosylation, cleaves a single known substrate-the so-called HCF-1PRO repeat of the transcriptional co-regulator host-cell factor 1 (HCF-1). Glutamic Acid O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens
2 Using serine- or glutamate-containing HCF-1PRO-repeat sequences, we show that proposed OGT-based or UDP-GlcNAc-based serine-acceptor residue activation mechanisms can be circumvented independently, but not when disrupted together. Glutamic Acid O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens