Title : Red nucleus interleukin-1β evokes tactile allodynia through activation of JAK/STAT3 and JNK signaling pathways.

Pub. Date : 2018 Dec

PMID : 30216497






1 Functional Relationships(s)
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1 Further studies demonstrated that injection of the JAK2 antagonist AG490 or JNK antagonist SP600125 into the RN 30 min prior to the administration of rrIL-1beta could completely prevent IL-1beta-evoked tactile allodynia, while injection of the ERK antagonist PD98059, p38 MAPK antagonist SB203580, or NF-kappaB antagonist PDTC did not affect IL-1beta-evoked tactile allodynia. SB 203580 mitogen-activated protein kinase 8 Rattus norvegicus