Pub. Date : 1986 Oct
PMID : 3020563
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In vivo evidence that cGMP is the second messenger for atrial natriuretic factor. | Cyclic GMP | natriuretic peptide A | Homo sapiens |
| 2 | cGMP generation has been associated with many of the vascular and endocrine actions of atrial natriuretic factor (ANF) in vitro. | Cyclic GMP | natriuretic peptide A | Homo sapiens |
| 3 | cGMP generation has been associated with many of the vascular and endocrine actions of atrial natriuretic factor (ANF) in vitro. | Cyclic GMP | natriuretic peptide A | Homo sapiens |
| 4 | To examine the role of cGMP as a second messenger for the renal hemodynamic action of ANF in vivo, we measured glomerular filtration rate (GFR) and cGMP concentration in systemic artery, renal vein, and urine as well as in Bowman"s space and end-proximal tubule (by free-flow micropuncture) after administration of ANF. | Cyclic GMP | natriuretic peptide A | Homo sapiens |
| 5 | ANF increased GFR by 45% and simultaneously induced a greater than 5-fold increase of cGMP concentration in glomerular ultrafiltrate (Bowman"s space) when compared to controls. | Cyclic GMP | natriuretic peptide A | Homo sapiens |
| 6 | Although a small amount of tubular handling of cGMP occurred along the length of the nephron, the augmented cGMP production from the glomerulus accounted for most of the 10- to 12-fold higher urinary cGMP excretion observed after ANF administration. | Cyclic GMP | natriuretic peptide A | Homo sapiens |
| 7 | Although a small amount of tubular handling of cGMP occurred along the length of the nephron, the augmented cGMP production from the glomerulus accounted for most of the 10- to 12-fold higher urinary cGMP excretion observed after ANF administration. | Cyclic GMP | natriuretic peptide A | Homo sapiens |
| 8 | Thus, ANF markedly stimulated glomerular production of cGMP, which coincided with a marked increase in GFR. | Cyclic GMP | natriuretic peptide A | Homo sapiens |
| 9 | Since dibutyryl cGMP itself was capable of increasing GFR, cGMP is the likely second messenger for ANF in vivo. | Cyclic GMP | natriuretic peptide A | Homo sapiens |