Pub. Date : 2018 Dec
PMID : 30205091
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Methadone undergoes N-demethylation by multiple cytochrome P450 (CYP) enzymes including CYP3A4, CYP2B6, CYP2C19, CYP2D6, CYP2C9, and CYP2C8. | Methadone | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 2 | Methadone undergoes N-demethylation by multiple cytochrome P450 (CYP) enzymes including CYP3A4, CYP2B6, CYP2C19, CYP2D6, CYP2C9, and CYP2C8. | Methadone | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 3 | In general, CYP inhibitors altered methadone exposure with no adverse effects. | Methadone | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 4 | CYP inducers generally decreased methadone exposure with some reports of withdrawal symptoms in the subjects. | Methadone | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 5 | For certain antiviral medicines which are dual inhibitor(s) and inducer(s) for CYP enzymes, their effect on methadone pharmacokinetics can change with time since the effect of induction is usually delayed compared to the effect of inhibition. | Methadone | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |