Title : Re-evaluation of mouse tissue factor pathway inhibitor and comparison of mouse and human tissue factor pathway inhibitor physiology.

Pub. Date : 2018 Nov

PMID : 30194803






2 Functional Relationships(s)
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1 Results Mouse TFPI and human TFPI are similar in regard to: (i) the mechanisms for FVIIa/TF and FXa inhibition; (ii) TFPIalpha is a soluble form and TFPIbeta is glycosyl phosphatidyl inositol (GPI) membrane anchored; (iii) the predominant circulating form of TFPI in plasma is lipoprotein-associated; (iv) low levels of TFPIalpha circulate in plasma and increase following heparin treatment; and (v) TFPIalpha is the isoform in platelets. Heparin tissue factor pathway inhibitor Homo sapiens
2 Results Mouse TFPI and human TFPI are similar in regard to: (i) the mechanisms for FVIIa/TF and FXa inhibition; (ii) TFPIalpha is a soluble form and TFPIbeta is glycosyl phosphatidyl inositol (GPI) membrane anchored; (iii) the predominant circulating form of TFPI in plasma is lipoprotein-associated; (iv) low levels of TFPIalpha circulate in plasma and increase following heparin treatment; and (v) TFPIalpha is the isoform in platelets. Heparin tissue factor pathway inhibitor Homo sapiens