Protein Name tissue factor pathway inhibitor
Organism Homo sapiens
Gene ID 7035
Gene Symbol


UniProt P10646 (TFPI1_HUMAN)
Relationships Total Number of functionally related compound(s) : 325
Total Number of Articles : 477

tissue factor pathway inhibitor

Gene Summary

This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization. [provided by RefSeq, Jul 2016]

  • tissue factor pathway inhibitor
  • anti-convertin
  • extrinsic pathway inhibitor
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