Title : Targeting the paracrine hormone-dependent guanylate cyclase/cGMP/phosphodiesterases signaling pathway for colorectal cancer prevention.

Pub. Date : 2019 Jun

PMID : 30189250






1 Functional Relationships(s)
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1 PDE5-specific inhibitors, such as sildenafil, show considerable anti-tumorigenic potential against CRC by amplifying the GUCY2C/cGMP signaling pathway, but cannot achieve complete anti-tumorigenic effects. Sildenafil Citrate phosphodiesterase 5A Homo sapiens