Pub. Date : 2019 Feb
PMID : 30178545
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin is the key factor in elevated plasma growth differentiation factor-15 levels in type 2 diabetes: A nested, case-control study. | Metformin | growth differentiation factor 15 | Homo sapiens |
| 2 | Produced as a tissue defence response to hypoxia and inflammation, growth differentiation factor-15 (GDF-15) is elevated in people receiving metformin treatment. | Metformin | growth differentiation factor 15 | Homo sapiens |
| 3 | Produced as a tissue defence response to hypoxia and inflammation, growth differentiation factor-15 (GDF-15) is elevated in people receiving metformin treatment. | Metformin | growth differentiation factor 15 | Homo sapiens |
| 4 | To gain insight into the relationship of GDF-15 with metformin and major cardiovascular risk factors, we analysed the data from the SUMMIT cohort (n = 1438), a four-centre, nested, case-control study aimed at verifying whether biomarkers of atherosclerosis differ according to the presence of type 2 diabetes and cardiovascular disease. | Metformin | growth differentiation factor 15 | Homo sapiens |
| 5 | In participants with diabetes, metformin treatment was associated with a 40% rise in GDF-15 level, which was independent of the other major factors, and largely explained their elevated GDF-15 levels. | Metformin | growth differentiation factor 15 | Homo sapiens |
| 6 | In participants with diabetes, metformin treatment was associated with a 40% rise in GDF-15 level, which was independent of the other major factors, and largely explained their elevated GDF-15 levels. | Metformin | growth differentiation factor 15 | Homo sapiens |
| 7 | The relatively high GDF-15 bioavailability might partly explain the protective cardiovascular effects of metformin. | Metformin | growth differentiation factor 15 | Homo sapiens |