Pub. Date : 2019 Jan
PMID : 30177833
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Desuppression of TGF-beta signaling via nuclear c-Abl-mediated phosphorylation of TIF1gamma/TRIM33 at Tyr-524, -610, and -1048. | Tyrosine | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 2 | Replacement of the three tyrosine residues Tyr-524, -610, and -1048 with phenylalanine (3YF) inhibits c-Abl-mediated phosphorylation of TIF1gamma and enhances TIF1gamma"s association with Smad3. | Tyrosine | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 3 | Replacement of the three tyrosine residues Tyr-524, -610, and -1048 with phenylalanine (3YF) inhibits c-Abl-mediated phosphorylation of TIF1gamma and enhances TIF1gamma"s association with Smad3. | Tyrosine | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 4 | Intriguingly, activation of c-Abl by epidermal growth factor (EGF) induces desuppression of TGF-beta signaling via enhancing the tyrosine phosphorylation level of TIF1gamma. | Tyrosine | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 5 | These results suggest that nuclear c-Abl-mediated tyrosine phosphorylation of TIF1gamma has a desuppressive role in TGF-beta-Smad2/3 signaling. | Tyrosine | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |