Title : Genetic and pharmacological inhibition of eIF4E effectively targets esophageal cancer cells and augments 5-FU's efficacy.

Pub. Date : 2018 Jul

PMID : 30174840






5 Functional Relationships(s)
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1 Of note, the sensitivity of esophageal cancer cells to ribavirin or eIF4E knockdown correlates well with the expression levels of eIF4E, demonstrating that esophageal cells with higher eIF4E expression are more sensitive to eIF4E inhibition. Ribavirin eukaryotic translation initiation factor 4E Homo sapiens
2 Of note, the sensitivity of esophageal cancer cells to ribavirin or eIF4E knockdown correlates well with the expression levels of eIF4E, demonstrating that esophageal cells with higher eIF4E expression are more sensitive to eIF4E inhibition. Ribavirin eukaryotic translation initiation factor 4E Homo sapiens
3 Of note, the sensitivity of esophageal cancer cells to ribavirin or eIF4E knockdown correlates well with the expression levels of eIF4E, demonstrating that esophageal cells with higher eIF4E expression are more sensitive to eIF4E inhibition. Ribavirin eukaryotic translation initiation factor 4E Homo sapiens
4 We further confirmed that the mechanism of action of ribavirin on esophageal cancer cells was through suppressing the Akt/mTOR/eIF4E and eIF4E-regulated pathways. Ribavirin eukaryotic translation initiation factor 4E Homo sapiens
5 We further confirmed that the mechanism of action of ribavirin on esophageal cancer cells was through suppressing the Akt/mTOR/eIF4E and eIF4E-regulated pathways. Ribavirin eukaryotic translation initiation factor 4E Homo sapiens