Pub. Date : 2018 Aug 29
PMID : 30157958
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | HMGB1 knockdown in MM cells enhanced the inhibitory effect of chemotherapy with dexamethasone (Dex) via apoptosis induction. | Dexamethasone | high mobility group box 1 | Homo sapiens |
| 2 | HMGB1 knockdown in MM cells enhanced the inhibitory effect of chemotherapy with dexamethasone (Dex) via apoptosis induction. | Dexamethasone | high mobility group box 1 | Homo sapiens |
| 3 | Furthermore, downregulation of HMGB1 activated the mTOR pathway, inhibited autophagy and increased DNA damage induced by Dex by modulating expression of related genes. | Dexamethasone | high mobility group box 1 | Homo sapiens |
| 4 | CONCLUSIONS: Our research shows that HMGB1 participates in autophagy and DNA damage repair and that downregulation of HMGB1 enhances the sensitivity of MM cells to Dex, suggesting that HMGB1 may serve as a target for MM treatment. | Dexamethasone | high mobility group box 1 | Homo sapiens |
| 5 | CONCLUSIONS: Our research shows that HMGB1 participates in autophagy and DNA damage repair and that downregulation of HMGB1 enhances the sensitivity of MM cells to Dex, suggesting that HMGB1 may serve as a target for MM treatment. | Dexamethasone | high mobility group box 1 | Homo sapiens |