Title : Catalytic Reaction Mechanism in Native and Mutant Catechol- O-methyltransferase from the Adaptive String Method and Mean Reaction Force Analysis.

Pub. Date : 2018 Sep 27

PMID : 30157632






1 Functional Relationships(s)
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1 Our results show that the native enzyme limits the access of water molecules to the active site, enhancing the interaction between the reactants and providing a more favorable electrostatic environment to assist the SN2 methyl transfer reaction. Water solute carrier family 38 member 5 Homo sapiens