PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30157632-5 2018 Our results show that the native enzyme limits the access of water molecules to the active site, enhancing the interaction between the reactants and providing a more favorable electrostatic environment to assist the SN2 methyl transfer reaction. Water 61-66 solute carrier family 38 member 5 Homo sapiens 216-219