Title : Retinoic Acid Receptor α Knockdown Suppresses the Tumorigenicity of Esophageal Carcinoma via Wnt/β-catenin Pathway.

Pub. Date : 2018 Dec

PMID : 30155836






1 Functional Relationships(s)
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1 Mechanistically, RARalpha knockdown inhibited the activity of Wnt/beta-catenin pathway through reducing the phosphorylation level of GSK3beta at Ser-9 and inducing phosphorylation level at Tyr-216, which resulted in downregulation of its downstream targets such as MMP7, MMP9, and P-gP. Tyrosine catenin beta 1 Homo sapiens