Title : Retinoic Acid Receptor α Knockdown Suppresses the Tumorigenicity of Esophageal Carcinoma via Wnt/β-catenin Pathway.

Pub. Date : 2018 Dec

PMID : 30155836

1 Functional Relationships(s)
Compound Name
Protein Name
1 Mechanistically, RARalpha knockdown inhibited the activity of Wnt/beta-catenin pathway through reducing the phosphorylation level of GSK3beta at Ser-9 and inducing phosphorylation level at Tyr-216, which resulted in downregulation of its downstream targets such as MMP7, MMP9, and P-gP. Tyrosine catenin beta 1 Homo sapiens