Pub. Date : 2018 Aug 28
PMID : 30154433
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In acquired sorafenib-resistant cells, ID1 low expression, p16/IL6 axis up-regulation, and AKT phosphorylation activation were observed. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | A reduced cytotoxicity of sorafenib was detected when sorafenib-sensitive cells incubated with conditioned media from the resistant cells, accompanied by the stimulation of AKT phosphorylation. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | The reversal of sorafenib resistance could be achieved through ID1 overexpression, IL6 blocking, and AKT pathway inhibition. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |