PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30154433-9 2018 In acquired sorafenib-resistant cells, ID1 low expression, p16/IL6 axis up-regulation, and AKT phosphorylation activation were observed. Sorafenib 12-21 AKT serine/threonine kinase 1 Homo sapiens 91-94 30154433-10 2018 A reduced cytotoxicity of sorafenib was detected when sorafenib-sensitive cells incubated with conditioned media from the resistant cells, accompanied by the stimulation of AKT phosphorylation. Sorafenib 26-35 AKT serine/threonine kinase 1 Homo sapiens 173-176 30154433-11 2018 The reversal of sorafenib resistance could be achieved through ID1 overexpression, IL6 blocking, and AKT pathway inhibition. Sorafenib 16-25 AKT serine/threonine kinase 1 Homo sapiens 101-104