Title : O2 Activation by Nonheme FeII α-Ketoglutarate-Dependent Enzyme Variants: Elucidating the Role of the Facial Triad Carboxylate in FIH.

Pub. Date : 2018 Sep 19

PMID : 30148961






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 FIH [factor inhibiting HIF (hypoxia inducible factor)] is an alpha-ketoglutarate (alphaKG)-dependent nonheme iron enzyme that catalyzes the hydroxylation of the C-terminal transactivation domain (CAD) asparagine residue in HIF-1alpha to regulate cellular oxygen levels. Iron hypoxia inducible factor 1 subunit alpha Homo sapiens