Title : Hypoxic preconditioning attenuates necroptotic neuronal death induced by global cerebral ischemia via Drp1-dependent signaling pathway mediated by CaMKIIα inactivation in adult rats.

Pub. Date : 2019 Jan

PMID : 30148677






1 Functional Relationships(s)
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1 We also found that HPC decreased the expression and the activity of caspase-8 in CA1 after tGCI, and notably, the pretreatment with Z-VAD-FMK, a pan-caspase inhibitor, did not trigger necroptosis but attenuated the tGCI-induced neuronal damage. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone caspase 8 Rattus norvegicus