Title : [Effects of FK866 on migration of A549 cells and related mechanism].

Pub. Date : 2018 Jan 25

PMID : 30146805






2 Functional Relationships(s)
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1 The mRNA expression of E-cadherin and vimentin, and the activated ERK1/2 were significantly increased after 1.0 nmol/L FK866 treatment for 72 h. The pretreatment with nicotinamide adenine dinucleotide (NAD) precursor nicotinamide mononucleotide(1.0 mmol/L) or ERK1/2 inhibitor U0126 (10.0 mumol/L) reversed the up-regulation of E-cadherin and vimentin expression induced by FK866. NAD vimentin Homo sapiens
2 The mRNA expression of E-cadherin and vimentin, and the activated ERK1/2 were significantly increased after 1.0 nmol/L FK866 treatment for 72 h. The pretreatment with nicotinamide adenine dinucleotide (NAD) precursor nicotinamide mononucleotide(1.0 mmol/L) or ERK1/2 inhibitor U0126 (10.0 mumol/L) reversed the up-regulation of E-cadherin and vimentin expression induced by FK866. NAD vimentin Homo sapiens