Title : In vitro evaluation of effects of metformin on morphine and methadone tolerance through mammalian target of rapamycin signaling pathway.

Pub. Date : 2019 Mar

PMID : 30146703






1 Functional Relationships(s)
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1 Contribution of mTOR signaling pathway in metformin-induced effect was shown by the inhibition of phosphorylation of S6K1 and 4E-BP1, the downstream targets of mTOR. Metformin ribosomal protein S6 kinase B1 Homo sapiens