Pub. Date : 2018 Nov
PMID : 30145470
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 4-Methylcatechol prevents streptozotocin-induced acute kidney injury through modulating NGF/TrkA and ROS-related Akt/GSK3beta/beta-catenin pathways. | 4-methylcatechol | glycogen synthase kinase 3 beta | Homo sapiens |
| 2 | Moreover, 4MC pre-treatment increased levels of NGF and its receptor TrkA, p-Akt (Thr308), p-GSK3beta (Ser9) and nuclear beta-catenin. | 4-methylcatechol | glycogen synthase kinase 3 beta | Homo sapiens |
| 3 | These data suggest that 4MC prevents the development of STZ-induced renal damage by suppressing ROS production and inflammation via Akt/GSK3beta/beta-catenin pathway which may be stimulated by NGF/TrkA signaling. | 4-methylcatechol | glycogen synthase kinase 3 beta | Homo sapiens |