Title : 7-Methoxy-luteolin-8-C-β-6-deoxy-xylo-pyranos-3-uloside exactly (mLU8C-PU) isolated from Arthraxon hispidus inhibits migratory and invasive responses mediated via downregulation of MMP-9 and IL-8 expression in MCF-7 breast cancer cells.

Pub. Date : 2018 Nov

PMID : 30133131






2 Functional Relationships(s)
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1 TPA-induced membrane translocation of PKCalpha, phosphorylation of JNK, and the nuclear translocations of AP-1 and NF-kappaB were downregulated by mLU8C-PU in MCF-7 cells. Tetradecanoylphorbol Acetate mitogen-activated protein kinase 8 Homo sapiens
2 These results indicate that mLU8C-PU inhibits migratory and invasive responses in MCF-7 breast cancer cells by suppressing MMP-9 and IL-8 expression through mitigating TPA-induced PKCalpha, JNK activation, and the nuclear translocation of AP-1 and NF-kappaB. Tetradecanoylphorbol Acetate mitogen-activated protein kinase 8 Homo sapiens