Title : Epithelial-mesenchymal transition (EMT) beyond EGFR mutations per se is a common mechanism for acquired resistance to EGFR TKI.

Pub. Date : 2019 Jan

PMID : 30111817






1 Functional Relationships(s)
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1 Here we report that NSCLC cells with acquired resistance to gefitinib or osimertinib (AZD9291) exhibit EMT features, with a decrease in E-cadherin, and increases in vimentin and stemness, without possessing any EGFR secondary mutations. osimertinib epidermal growth factor receptor Homo sapiens