Pub. Date : 2017 Jul 1
PMID : 30108853
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Side chain-functionalized aniline-derived ursolic acid derivatives as multidrug resistance reversers that block the nuclear factor-kappa B (NF-kappaB) pathway and cell proliferation. | ursolic acid | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Side chain-functionalized aniline-derived ursolic acid derivatives as multidrug resistance reversers that block the nuclear factor-kappa B (NF-kappaB) pathway and cell proliferation. | ursolic acid | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | A series of inhibitors of NF-kappaB based on ursolic acid (UA) derivatives containing functionalized aniline or amide side chains were synthesized and evaluated for inhibition of NF-kappaB as well as their antitumor effects. | ursolic acid | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | A series of inhibitors of NF-kappaB based on ursolic acid (UA) derivatives containing functionalized aniline or amide side chains were synthesized and evaluated for inhibition of NF-kappaB as well as their antitumor effects. | ursolic acid | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | Thus, the rational design of UA derivatives with functionalized aniline or amide side chains offers significant potential for the discovery of a new class of NF-kappaB inhibitors with the ability to induce apoptosis and reverse multidrug resistance in the NCI-H460 lung adenocarcinoma cell line. | ursolic acid | nuclear factor kappa B subunit 1 | Homo sapiens |