Title : Small structural changes of the imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitors produce an improved safety profile.

Pub. Date : 2017 Apr 1

PMID : 30108796






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Herein, we report the first toxicological evaluation of imidazopyridine-based DGAT2 inhibitors and show that the arteriopathy associated with imidazopyridine 1 can be mitigated with small structural modifications, and is thus not mechanism related. imidazopyridine 1 acyl-CoA wax alcohol acyltransferase 1 Homo sapiens