Title : Glucose suppresses IL-1β-induced MMP-1 expression through the FAK, MEK, ERK, and AP-1 signaling pathways.

Pub. Date : 2018 Oct

PMID : 30098273






1 Functional Relationships(s)
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1 Analyses using a focal adhesion kinase (FAK) inhibitor, MEK inhibitors (U0126 and PD98059), an ERK inhibitor, AP-1 inhibitors (curcumin and tanshinone), or siRNAs demonstrated that the FAK, MEK, ERK, and AP-1 pathways mediate IL-1beta-induced increases in MMP-1 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one protein tyrosine kinase 2 Homo sapiens