Pub. Date : 2018 Aug 21
PMID : 30097175
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our simulations indicate that KRas4B-GTP interacts with the REM allosteric site more strongly than with the CDC25 catalytic site, consistent with its allosteric role in the GDP-to-GTP exchange. | Guanosine Triphosphate | KRAS proto-oncogene, GTPase | Homo sapiens |
| 2 | The conformational change facilitates loading KRas4B-GDP at the catalytic site and opening the KRas4B nucleotide-binding site for GDP release and GTP binding. | Guanosine Triphosphate | KRAS proto-oncogene, GTPase | Homo sapiens |
| 3 | The conformational change facilitates loading KRas4B-GDP at the catalytic site and opening the KRas4B nucleotide-binding site for GDP release and GTP binding. | Guanosine Triphosphate | KRAS proto-oncogene, GTPase | Homo sapiens |
| 4 | GTP binding reduces the affinity of KRas4B-GTP to the CDC25 catalytic site, resulting in its release. | Guanosine Triphosphate | KRAS proto-oncogene, GTPase | Homo sapiens |