Title : 14-3-3γ binds regulator of G protein signaling 14 (RGS14) at distinct sites to inhibit the RGS14:Gαi-AlF4- signaling complex and RGS14 nuclear localization.

Pub. Date : 2018 Sep 21

PMID : 30093406






3 Functional Relationships(s)
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1 Using bioluminescence resonance energy transfer (BRET), we show that the pSer-218-dependent RGS14/14-3-3gamma interaction inhibits active Galphai1-AlF4- binding to the RGS domain of RGS14 but has no effect on active H-Ras and inactive Galphai1-GDP binding to RGS14. Guanosine Diphosphate regulator of G protein signaling 14 Homo sapiens
2 Using bioluminescence resonance energy transfer (BRET), we show that the pSer-218-dependent RGS14/14-3-3gamma interaction inhibits active Galphai1-AlF4- binding to the RGS domain of RGS14 but has no effect on active H-Ras and inactive Galphai1-GDP binding to RGS14. Guanosine Diphosphate regulator of G protein signaling 14 Homo sapiens
3 Using bioluminescence resonance energy transfer (BRET), we show that the pSer-218-dependent RGS14/14-3-3gamma interaction inhibits active Galphai1-AlF4- binding to the RGS domain of RGS14 but has no effect on active H-Ras and inactive Galphai1-GDP binding to RGS14. Guanosine Diphosphate regulator of G protein signaling 14 Homo sapiens