| Protein Name | regulator of G protein signaling 14 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 10636 |
| Gene Symbol | RGS14 |
| UniProt | O43566 (RGS14_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
32
Total Number of Articles : 32 |
Description |
regulator of G protein signaling 14 |
| Gene Summary |
This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] |
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