Title : Estradiol Increases Glutamate and GABA Neurotransmission into GnRH Neurons via Retrograde NO-Signaling in Proestrous Mice during the Positive Estradiol Feedback Period.

Pub. Date : 2018 Jul-Aug

PMID : 30079374






1 Functional Relationships(s)
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1 These results indicate that estradiol acts directly on GnRH neurons via the ERbeta/Akt/nNOS pathway at proestrus afternoon generating NO that retrogradely accelerates GABA and glutamate release from the presynaptic terminals contacting GnRH neurons. Estradiol estrogen receptor 2 (beta) Mus musculus