Pub. Date : 2019 Mar
PMID : 30066962
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resveratrol inhibits Erk1/2-mediated adhesion of cancer cells via activating PP2A-PTEN signaling network. | Resveratrol | protein phosphatase 2 phosphatase activator | Homo sapiens |
| 2 | Further research revealed that both protein phosphatase 2A (PP2A) and phosphatase and tensin homolog (PTEN)-Akt were implicated in resveratrol-inactivated Erk1/2-dependent cell adhesion. | Resveratrol | protein phosphatase 2 phosphatase activator | Homo sapiens |
| 3 | Inhibition of PP2A with okadaic acid or overexpression of dominant-negative PP2A rendered resistance to resveratrol"s suppression of the basal or IGF-1-stimulated phospho-Erk1/2 and cell adhesion, whereas expression of wild-type PP2A enhanced resveratrol"s inhibitory effects. | Resveratrol | protein phosphatase 2 phosphatase activator | Homo sapiens |
| 4 | Inhibition of PP2A with okadaic acid or overexpression of dominant-negative PP2A rendered resistance to resveratrol"s suppression of the basal or IGF-1-stimulated phospho-Erk1/2 and cell adhesion, whereas expression of wild-type PP2A enhanced resveratrol"s inhibitory effects. | Resveratrol | protein phosphatase 2 phosphatase activator | Homo sapiens |
| 5 | Inhibition of PP2A with okadaic acid or overexpression of dominant-negative PP2A rendered resistance to resveratrol"s suppression of the basal or IGF-1-stimulated phospho-Erk1/2 and cell adhesion, whereas expression of wild-type PP2A enhanced resveratrol"s inhibitory effects. | Resveratrol | protein phosphatase 2 phosphatase activator | Homo sapiens |
| 6 | Inhibition of PP2A with okadaic acid or overexpression of dominant-negative PP2A rendered resistance to resveratrol"s suppression of the basal or IGF-1-stimulated phospho-Erk1/2 and cell adhesion, whereas expression of wild-type PP2A enhanced resveratrol"s inhibitory effects. | Resveratrol | protein phosphatase 2 phosphatase activator | Homo sapiens |
| 7 | Inhibition of PP2A with okadaic acid or overexpression of dominant-negative PP2A rendered resistance to resveratrol"s suppression of the basal or IGF-1-stimulated phospho-Erk1/2 and cell adhesion, whereas expression of wild-type PP2A enhanced resveratrol"s inhibitory effects. | Resveratrol | protein phosphatase 2 phosphatase activator | Homo sapiens |
| 8 | Inhibition of PP2A with okadaic acid or overexpression of dominant-negative PP2A rendered resistance to resveratrol"s suppression of the basal or IGF-1-stimulated phospho-Erk1/2 and cell adhesion, whereas expression of wild-type PP2A enhanced resveratrol"s inhibitory effects. | Resveratrol | protein phosphatase 2 phosphatase activator | Homo sapiens |
| 9 | Furthermore, inhibition of mechanistic/mammalian target of rapamycin (mTOR) with rapamycin or silencing mTOR enhanced resveratrol"s inhibitory effects on the basal and IGF-1-induced inhibition of PP2A-PTEN, activation of Akt-Erk1/2, and cell adhesion. | Resveratrol | protein phosphatase 2 phosphatase activator | Homo sapiens |
| 10 | The results indicate that resveratrol inhibits Erk1/2-mediated adhesion of cancer cells via activating PP2A-PTEN signaling network. | Resveratrol | protein phosphatase 2 phosphatase activator | Homo sapiens |