Pub. Date : 2018 Sep
PMID : 30066892
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Icariin promotes the proliferation and differentiation of osteoblasts from the rat mandible by the Wnt/beta-catenin signalling pathway. | icariin | catenin beta 1 | Rattus norvegicus |
| 2 | Furthermore, ICA elevated the mRNA expression levels of beta-catenin, runt-related transcription factor 2, cyclin D1 and alkaline phosphatase in osteoblastic cells, and these effects were inhibited by the Wnt/beta-catenin pathway inhibitor Dickkopf-1; thus, the Wnt/beta-catenin signalling pathway may be involved with the ICA-induced proliferation and differentiation of osteoblasts from the rat mandible. | icariin | catenin beta 1 | Rattus norvegicus |
| 3 | Furthermore, ICA elevated the mRNA expression levels of beta-catenin, runt-related transcription factor 2, cyclin D1 and alkaline phosphatase in osteoblastic cells, and these effects were inhibited by the Wnt/beta-catenin pathway inhibitor Dickkopf-1; thus, the Wnt/beta-catenin signalling pathway may be involved with the ICA-induced proliferation and differentiation of osteoblasts from the rat mandible. | icariin | catenin beta 1 | Rattus norvegicus |
| 4 | Furthermore, ICA elevated the mRNA expression levels of beta-catenin, runt-related transcription factor 2, cyclin D1 and alkaline phosphatase in osteoblastic cells, and these effects were inhibited by the Wnt/beta-catenin pathway inhibitor Dickkopf-1; thus, the Wnt/beta-catenin signalling pathway may be involved with the ICA-induced proliferation and differentiation of osteoblasts from the rat mandible. | icariin | catenin beta 1 | Rattus norvegicus |
| 5 | Furthermore, ICA elevated the mRNA expression levels of beta-catenin, runt-related transcription factor 2, cyclin D1 and alkaline phosphatase in osteoblastic cells, and these effects were inhibited by the Wnt/beta-catenin pathway inhibitor Dickkopf-1; thus, the Wnt/beta-catenin signalling pathway may be involved with the ICA-induced proliferation and differentiation of osteoblasts from the rat mandible. | icariin | catenin beta 1 | Rattus norvegicus |
| 6 | Furthermore, ICA elevated the mRNA expression levels of beta-catenin, runt-related transcription factor 2, cyclin D1 and alkaline phosphatase in osteoblastic cells, and these effects were inhibited by the Wnt/beta-catenin pathway inhibitor Dickkopf-1; thus, the Wnt/beta-catenin signalling pathway may be involved with the ICA-induced proliferation and differentiation of osteoblasts from the rat mandible. | icariin | catenin beta 1 | Rattus norvegicus |
| 7 | In conclusion, these results support the osteogenic effects of ICA (0.15 to 15 microM) on osteoblastic cells from the rat mandible and the participation of the Wnt/beta-catenin signalling pathway. | icariin | catenin beta 1 | Rattus norvegicus |