Pub. Date : 2018 Sep 1
PMID : 30060118
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The FoxM1-ABCC4 axis mediates carboplatin resistance in human retinoblastoma Y-79 cells. | Carboplatin | forkhead box M1 | Homo sapiens |
| 2 | In this study, we investigated the regulatory effect of FoxM1 on carboplatin resistance in human RB Y-79 cells and carboplatin-resistant Y-79 (Y-79CR) cells, as well as the possible mechanism. | Carboplatin | forkhead box M1 | Homo sapiens |
| 3 | Our results showed that FoxM1 was up-regulated in Y-79CR cells and silencing of FoxM1 promoted carboplatin sensitivity and accumulation, while overexpression of FoxM1 in Y-79 cells performed oppositely. | Carboplatin | forkhead box M1 | Homo sapiens |
| 4 | Our results showed that FoxM1 was up-regulated in Y-79CR cells and silencing of FoxM1 promoted carboplatin sensitivity and accumulation, while overexpression of FoxM1 in Y-79 cells performed oppositely. | Carboplatin | forkhead box M1 | Homo sapiens |
| 5 | Our results showed that FoxM1 was up-regulated in Y-79CR cells and silencing of FoxM1 promoted carboplatin sensitivity and accumulation, while overexpression of FoxM1 in Y-79 cells performed oppositely. | Carboplatin | forkhead box M1 | Homo sapiens |
| 6 | Our study further revealed that FoxM1 enhanced carboplatin resistance in Y-79CR cells through directly up-regulating the transcription of ATP-binding cassette transporter C4 (ABCC4), an important drug efflux transporter. | Carboplatin | forkhead box M1 | Homo sapiens |
| 7 | Overall, our study demonstrated the novel role of FoxM1-ABCC4 axis in human RB, which provides insights into the prevention of carboplatin resistance in human RB. | Carboplatin | forkhead box M1 | Homo sapiens |