Pub. Date : 2018 Nov 30
PMID : 30055307
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The results showed that the expression of HMGB1 was increased in human umbilical vein endothelial cells (HUVECs) after exposure to high glucose (25 mM). | Glucose | high mobility group box 1 | Homo sapiens |
| 2 | Downregulation of HMGB1 attenuated the high glucose-induced antiangiogenesis of HUVECs, and the decrease expression of HMGB1 inhibiting HUVEC apoptosis and inflammatory factor expression. | Glucose | high mobility group box 1 | Homo sapiens |
| 3 | However, HMGB1 overexpression attenuated the protective effect of miR-106 on HUVECs in high glucose conditions. | Glucose | high mobility group box 1 | Homo sapiens |
| 4 | Taken together, these data collectively suggested that miR-106 was a potential molecular target for inhibiting high glucose-induced inflammation and apoptosis by targeting HMGB1. | Glucose | high mobility group box 1 | Homo sapiens |