PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30050935-5	2018	As anticipated, TMZ caused DNA damage mediated by the ATM/p53/p21 signaling pathway and induced significant G2 delay.	Temozolomide	16-19	tumor protein p53	Homo sapiens	58-61	
30050935-7	2018	Mechanistic study showed that coadministration of caffeine and TMZ suppressed the phosphorylation of ATM and p53 and downregulated p21 expression, thus releasing DNA-damaged cells from G2 arrest into premature mitosis.	Temozolomide	63-66	tumor protein p53	Homo sapiens	109-112	
30050935-10	2018	In conclusion, our study demonstrated that caffeine enhanced the efficacy of TMZ through mitotic cell death by impeding ATM/p53/p21-mediated G2 arrest.	Temozolomide	77-80	tumor protein p53	Homo sapiens	124-127