Title : VKORC1L1, An Enzyme Mediating the Effect of Vitamin K in Liver and Extrahepatic Tissues.

Pub. Date : 2018 Jul 26

PMID : 30050002






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Vitamin K oxidoreductase (VKORC1) converts vitamin K epoxide into reduced vitamin K, which acts as the co-factor for the gamma-carboxylation of several proteins, including coagulation factors produced by the liver. Vitamin K vitamin K epoxide reductase complex subunit 1 Homo sapiens
2 Here, we first review the current knowledge on the structure, function and expression pattern of VKORC1L1, including recent data establishing that, in the absence of VKORC1, VKORC1L1 can support vitamin K-dependent carboxylation in the liver during the pre- and perinatal periods in vivo. Vitamin K vitamin K epoxide reductase complex subunit 1 Homo sapiens